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李军波

2021年05月25日 10:35  点击:[]

李军波 博士,教授,硕士研究导师,河南省青年骨干教师,学院副院长。E-mail: lijunbo@syokugaku.net

简介:2007年在南开大学获得博士学位,2015-2016年在美国麻省大学阿默斯特分校访问学者,合作导师为国际知名纳米材料科学家Vicent. Rotello教授。主要研究方向为功能高分子合成和抗癌药物载体设计,已在国际著名期刊Mater. today Chem., J. Bionanotechnol. 等杂志发表学术论文30余篇,第一授权专利5项,独著专著一部。河南省优秀基层教学组织主要负责人,主持完成河南省省教学改革项目1项,获得河南科技大学教学成果一等奖及教师教学一等奖各1项。

研究方向:功能高分子合成,高分子药物载体,肿瘤纳米诊断

科研项目:

1. 国家自然科学基金委员会,联合基金项目,U1705450,载体表面肿瘤微环境pHe-电荷响应灵敏度调控与基因传递效果,2018-012020-1250万元,结题,主持

2. 国家自然科学基金委员会,青年项目,51103035,离子液嵌段聚合物-金纳米粒子的阴离子传感器,2012-012014-1225万元,结题,主持

3. 河南省科技厅,河南省科技攻关项目,环境响应性药物载体的靶向控释与恶性肿瘤治疗效果,1821024100172018-012019-1210万元,结题,主持

4. 国家自然科学基金委员会,青年项目,51403055,多臂两亲性嵌合肽的设计、合成及基因/药物共传递,2015-012017-1225万元,结题,参加

近五年代表性论文

1. Biyu Zhou, Pengfei Cheng, Junting Jiang, Junyi Chen, Junbo Li*. Engineering polyzwitterion with acylsulfonamide-based betaine structure for protonated switch of surface chemistry at tumoral pH and reductive responsive drug release of polymeric micelles. Mater. Today Chem. 2020, 17, 100339.

2. Biyu Zhou, Junbo Li*, Binzhong Lu, Wenlan Wu, Leitao Zhang. Novel polyzwitterion shell with adaptable surface chemistry engineered to enhance anti-fouling and intracellular imaging of detonation nanodiamonds under tumor pH(e). Front. Mater. Sci, 2020, 14, 402.

3. Jingming Zhai, Biyu Zhou, Yanhui An, Binzhong Lu, Yonggang Fan, Junbo Li*. Galactosamine-Conjugating Zwitterionic Block Copolymer for Reduction-Responsive Release and Active Targeted Delivery of Doxorubicin to Hepatic Carcinoma Cells. J. Nanomateri. 2020, 7863709.

4. Junting Jiang, Junbo Li*, Biyu Zhou, Chaohuang Niu. Fabrication of Polymer Micelles with Zwitterionic Shell and Biodegradable Core for Reductively Responsive Release of Doxorubicin. Polymers, 2019, 11, 11061019.

5. Junbo Li*, Liang Lijuan, Liang Ju, Wu Wenlan, Zhou Huiyun and Guo Jinwu. Constructing Asymmetric Polyion Complex Vesicles via Template Assembling Strategy: Formulation Control and Tunable Permeability. Nanomaterials 2017, 7, 387.

6. Junting Jiang, Junbo Li*, Biyu Zhou, Chaohuang Niu. Synthesis of poly(ethylene glycol)-SS-poly(epsilon-caprolactone)-SS-poly(ethylene glycol) triblock copolymers via end-group conjugation and self-assembly for reductively responsive drug delivery. Front. Mater. Sci, 2019, 13, 410.

7. Junbo Li*, Sheng Zou, Jiayu Gao, Ju Liang, Huiyun Zhou, Lijuan Liang, Wenlan Wu. Block copolymer conjugated Au-coated Fe3O4 nanoparticles as vectors for enhancing colloidal stability and cellular uptake. J. Nanobiotechnol. 2017, 15(56).

8. Junbo Li*, Wenlan Wu, Jiayu Gao, Ju Liang, Huiyun Zhou and Lijuan Liang. Constructing of DNA vectors with controlled nanosize and single dispersion by block copolymer coating gold nanoparticles as template assembly. J. Naonopart. Res. 2017, 19, 86.

9. Junbo Li*, Jianlong Zhao, Jiayu Gao, Ju Liang, Wenlan Wu and Lijuan Liang. A block copolymer containing PEG and histamine-like segments: well-defined functions for gene delivery. New J. Chem., 2016, 40, 7222.

10. Junbo Li*, Ke Zhang, Ju Liang, Wenlan Wu, Jinwu Guo and Huiyun Zhou. Constructing one dimensional assembly of poly methylacrylic acid capping gold nanoparticles for selective and colorimetric detection of aminoglycoside antibiotics. RSC Advances, 2015, 5, 65690.

11. Junbo Li*, Jianlong Zhao, Wenlan Wu, Ju Liang, Jinwu Guo, Huiyun Zhou, Lijuan Liang. Temperature and anion responsive self-assembly of ionic liquid block copolymers coating gold nanoparticles. Front. Mater. Sci. 2016, 10, 178.

12. Ju Liang, Wenlan Wu, Junbo Li*, Chen Han, Shijie Zhang, Jinwu Guo, and Huiyun Zhou. Synthesis and self-assembly of temperature and anion double responsive ionic liquid block copolymers. Front. Mater. Sci., 2015, 9, 254.

13. Junbo Li*, Shijie Zhang, Ju Liang,Wenlan Wu, Jinwu Guo and Huiyun Zhou. Chain-like Arrangement of Gold Nanoparticles Coating a Polymeric Ionic Liquid Shell Via an Electrostatic Dipole Interaction. RSC Advances, 2015, 5, 799


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